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Recognizing the Primary Signs of Cognitive Decline

November 10, 2022Neelem Sheikh

As we age, many of us notice small changes in our cognitive abilities. Maybe you take longer to remember an old friend’s name or maybe you forget to pay a bill every once in a while. Throughout the aging process, your brain experiences minor structural changes, and consequently, you experience minor cognitive changes. But when are these changes a sign of cognitive decline?

Learning about the common signs of cognitive decline, the importance of routine cognitive testing, and how to measure cognitive changes can help you bring awareness to your brain health.

What Is Cognitive Decline?

Cognitive decline can range from Mild Cognitive Impairment (MCI) to dementia. Both are broad terms that indicate a decline in cognitive function greater than normal age-related decline. 

MCI is currently thought of as the stage between expected age-related cognitive decline and dementia. Individuals with MCI experience cognitive changes that are significant enough to be noticed by family and friends, but not significant enough to affect everyday function. MCI can be due to a variety of conditions, including neurological diseases such as Alzheimer’s disease and Parkinson’s disease and other conditions such as depression, thyroid problems, liver or kidney problems, and sleep disorders, among others. It’s important to note that having MCI does not necessarily mean you will go on to develop dementia. According to the Alzheimer’s Association, an estimated 10-15% of people living with MCI develop dementia each year. 

Dementia is an umbrella term used to describe a group of symptoms associated with a decline in memory, thinking, reasoning, or other cognitive abilities. These symptoms may include a decline in memory, changes in thinking or problem-solving abilities, poor reasoning and judgment skills, changes in language and communication abilities, and changes in personality and behavior.

There are several causes of dementia, including the following:

  • Alzheimer’s disease
  • Lewy Body dementia
  • Vascular dementia
  • Frontotemporal dementia
  • Mixed dementia
  • Huntington’s disease
  • Parkinson’s disease dementia
  • Creutzfeldt-Jakob disease
  • Posterior cortical atrophy

Many neurodegenerative diseases can be thought of as a continuum with distinct clinical phases. Within these continuums, MCI is often an early stage. For example, MCI due to Alzheimer’s disease is stage two of five in the Alzheimer’s disease continuum.

Signs of Cognitive Decline

As we mentioned above, there are many potential causes of cognitive decline. As a result, symptoms can vary depending on the cause and severity of cognitive decline. There are, however, signs of cognitive decline that may indicate you are experiencing a decline in function greater than the expected age-related decline. This may include:

  • Repeatedly asking the same questions
  • Getting lost in familiar places
  • Losing or misplacing things often
  • Difficulty understanding time and place
  • Forgetting important events, such as social engagements and appointments
  • Losing your train of thought or having difficulty coming up with the right word
  • Difficulty with decision-making or planning
  • Changes in judgment and impulse control
  • Struggling to follow a list of instructions (e.g., a recipe or driving directions).
  • Changes in mood (e.g., anxiety, depression, apathy, and irritability)

Routine medical check-ups and cognitive testing are key to detecting signs of cognitive decline as early as possible.

The Importance of Early, Routine Cognitive Screening

Approximately 75% of dementia cases go undiagnosed until it is too late. Like many other diseases and disorders, early intervention and early treatment of Alzheimer’s disease and other causes of dementia is believed to offer the best chance of therapeutic success and produce better health outcomes. 

Whether you’re 30 or 70, cognitive testing should be as normal as going to the dentist. It is never too early to prioritize and take charge of your brain health. After all, it is a vital part of overall wellness and plays a key role in our ability to live long, healthy, and full lives.

Measuring Cognitive Decline

To accurately measure cognitive decline, it is necessary to regularly and frequently assess brain function over time. By tracking trends and patterns in assessment scores longitudinally, signs of cognitive decline can be identified.

To do so, your healthcare provider may use cognitive assessment tools such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Mini-Cog, and the general practitioner assessment of cognition (GPCOG). These assessments typically require you to answer a series of questions and/or complete simple tasks to determine your cognitive abilities in areas such as learning and memory, orientation, attention, and visuospatial abilities. Assessments utilize scoring systems to quantify your cognitive function.

Unfortunately, these assessments don’t come without limitations. Most of these traditional assessments only assess a small subset of neurocognitive (cognitive and functional) domains. Because such assessments are not designed to analyze how we function in real-world settings, they often produce noisy, highly variable results that lack the specificity to detect small changes in cognition over time.

Reimagining Cognitive Testing

At Altoida, we believe that understanding your brain health should be simple and accessible. We are dedicated to providing patients with a reliable, affordable, and highly accurate way to measure and monitor brain health and detect cognitive decline. We are building the world’s-first Precision Neurology platform and app-based medical device—backed by 11 years of clinical validation—to accelerate and improve drug development, neurological disease research, and patient care.

By completing a 10-minute series of augmented reality and motor activities designed to simulate complex Activities of Daily Living on a smartphone or tablet, Altoida’s device extracts and provides robust measurements of neurocognitive function across 13 neurocognitive domains. Our device measures and analyzes nearly 800 multimodal cognitive and functional digital biomarkers. Through the collection of highly granular data from integrated smartphone or tablet sensors, Altoida’s device produces comprehensive neurocognitive domain scores. 

This method, along with our innovative artificial intelligence, will pioneer fully digital predictive neurological disease diagnosis. In 2021, our device received the Breakthrough Device designation by the FDA. Altoida's platform has demonstrated the ability to predict conversion from Mild Cognitive Impairment to Alzheimer's disease with a high degree of accuracy.

To learn more about the signs of cognitive decline, or about using Altoida’s Precision Neurology platform to monitor your brain health, contact us today.

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At Altoida, we use digital biomarkers to radically change the method of assessing brain health and cognitive diseases. After nearly two decades of research, we are developing a platform and device to measure and analyze cognitive biomarkers associated with cognitive impairment to evaluate perceptual and memory function.
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