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Cognitive Impairment in Parkinson's Disease: Understanding the Research

September 27, 2022Neelem Sheikh

Parkinson’s disease is a neurodegenerative disease that occurs when dopaminergic neurons in the substantia nigra stop working or die, resulting in a lack of dopamine, a chemical that coordinates movement and motor control. 

While Parkinson’s disease is considered a movement disorder, it is also associated with a diverse range of non-motor symptoms. Cognitive impairment in Parkinson’s disease is a common non-motor complication that can impact daily functioning, the course of treatment, and the required level of patient care.

In this article, we will discuss common cognitive changes in Parkinson’s disease patients, proposed causes of cognitive impairment, and methods for evaluating cognitive changes throughout the disease course to inform patient treatment and care.

Cognitive Impairment in Parkinson’s Disease

There is increased recognition that mild cognitive changes may be present at the time of Parkinson’s disease diagnosis or possibly early in the disease course. According to the Parkinson’s Foundation, approximately 50% of people with Parkinson’s disease will experience some form of cognitive impairment. While not all cases of cognitive impairment in Parkinson’s disease will lead to a dementia diagnosis, it is crucial to understand and recognize cognitive changes. 

Researchers have identified several cognitive domains commonly impacted in Parkinson’s disease. While affected domains may be limited to one or two early in the disease continuum, and the severity of impairment may vary from patient to patient, the following domains and subdomains of cognitive function are most often affected.

Complex Attention

Complex attention is our ability to focus on multiple things at once and our ability to choose what to pay attention to and what to ignore. Aspects or subdomains of complex attention that may be impacted in Parkinson’s disease include:

  • Cognitive processing speed: Cognitive processing speed refers to the rate at which relatively simple perceptual and automatic cognitive operations can be carried out.
  • Sustained attention: Sustained attention refers to the ability to focus on an activity or stimulus over extended periods of time.
  • Selective attention: Selective attention is the process of focusing on a particular input or stimuli while suppressing irrelevant or distracting information.
  • Divided attention: Divided attention refers to the ability to pay attention to multiple tasks or ideas at the same time.

Individuals with Parkinson’s disease may have delayed responses to verbal and/or behavioral stimuli, have difficulty retrieving information, or may take longer to complete tasks. They may have increased difficulty performing complex tasks that require them to sustain or shift their attention.

Executive Function

Executive functions refer to high-level cognitive abilities required to control and coordinate other cognitive abilities and behaviors. These are the functions needed to plan, prioritize, make decisions, respond to environments, and move between tasks. This includes all the sequencing, planning, and organization of sets of tasks. 

Changes in executive function can be present from the early stages of Parkinson’s disease and can cause deficits in internal control of attention, planning, inhibitory control, dual-task performance, and a range of decision-making tasks.

Memory

Memory functioning is one of the most complex and multifaceted cognitive domains and is composed of many subdomains, including working memory, procedural memory, and prospective memory, among others.

While changes in several subdomains of memory function are possible in Parkinson’s disease, working memory is most commonly impacted. Working memory refers to the small amount of information that can be held in mind and used in the execution of cognitive tasks. 

Visuospatial Ability

Visuospatial ability is a subdomain of perceptual-motor function and includes several cognitive abilities tied to the processing of visual information. It refers to the ability to identify visual and spatial relationships between objects. This includes pattern recognition (facial recognition), constructional ability (figure drawing), color recognition (color naming), and spatial analysis (ability to receive multiple objects in a visual field).

Individuals with Parkinson’s disease may have difficulty visualizing and interpreting their surroundings. They may have issues with measuring distances and depth perception, which is often exacerbated by low-light conditions.

Language

Language links strongly with the ability to communicate, whether through writing, reading, or speaking. Language abilities include things like naming objects, finding the right words, the fluidity and flow of speech patterns, grammar and syntax, and receptive language.

Language problems, especially those relating to voice and articulation, affect many Parkinson’s disease patients. Common characteristics of language impairment include:

  • Slowed and/or inaccurate verbal communication.
  • Deficits in verb inflection.
  • Deficits in verbal fluency.
  • Difficulty generating verbs.

What Causes Cognitive Impairment in Parkinson’s Disease?

The cause of cognitive impairment in Parkinson’s disease is not fully understood. Researchers hypothesize that the dopamine deficits observed in Parkison’s disease may play a role. Others hypothesize that changes in other chemical messengers, such as norepinephrine and acetylcholine, may be partly responsible for changes in memory and executive function.

It should be noted that in some cases, cognitive changes may also not be directly related to Parkinson’s disease itself. For example, thyroid dysfunction, which has been observed in more than 10% of Parkinson’s disease patients, can cause cognitive symptoms. Additionally, pneumonia and urinary tract infections are common complications of Parkinson’s disease and can acutely cause confusion and other cognitive symptoms.

Monitoring Cognitive Changes and Disease Progression

At Altoida, we are building the world’s-first Precision Neurology platform and app-based medical device—backed by 11 years of clinical validation—to accelerate and improve drug development, neurological disease research, and patient care.

By completing a 10-minute series of augmented reality and motor activities designed to simulate complex Activities of Daily Living on a smartphone or tablet, Altoida’s device extracts and provides robust measurements of neurocognitive function across 13 neurocognitive domains. Our device measures and analyzes nearly 800 multimodal cognitive and functional digital biomarkers. Through the collection of highly granular data from integrated smartphone or tablet sensors, Altoida’s device produces comprehensive neurocognitive domain scores. 

This data can be tracked longitudinally to reveal trends and patterns while flagging concerning ones. Through this feature, our technology will be utilized to monitor disease progression as well as to measure therapeutic response in Parkinson’s disease patients.

To learn more about cognitive impairment in Parkinson’s disease or about utilizing Altoida’s Precision Neurology platform, contact us today.

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